Title: Groundbreaking Pancreatic Cancer Treatment “Wakes Up” Immune Cells to Combat Deadly Disease In a groundbreaking development in cancer research, scientists have created an innovative antibody treatment that helps the immune system recognize and attack pancreatic cancer. This new therapy focuses on the sugars on the cell surface, blocking them so that immune cells can find and attack the cancer, according to researchers from Northwestern University in Chicago. Pancreatic cancer is notoriously difficult to treat due to its ability to hide effectively from the immune system. The cancer cells use a “sugary disguise” to trick the immune system into ignoring them. Most current cancer immunotherapies target proteins or genes, but this new therapy takes a different approach by focusing on the sugars that cover the cell surface. The study’s senior author, Mohamed Abdel-Mohsen, an associate professor of medicine in the division of infectious diseases at Northwestern University Feinberg School of Medicine, explained to Fox News Digital how pancreatic cancer cells use a molecule called sialic acid to “flip an immune ‘off switch’ on certain immune cells.” This signal essentially tells the immune system that these are normal, healthy cells and not to attack. In mice studies, this innovative treatment was successful in blocking this sugar signal, effectively “waking up” the immune cells and slowing down cancer growth. In two mouse models, tumors treated with the antibody grew significantly slower than those without treatment. This breakthrough has significant implications for pancreatic cancer patients who have limited options when it comes to effective treatments. The potential implications of this research are enormous as it offers a new approach in combating one of the deadliest forms of cancer. By focusing on the sugars that cover cell surfaces, researchers can potentially develop more targeted and effective therapies for various types of cancer. This could lead to better outcomes for patients who have been struggling with limited treatment options. In conclusion, this groundbreaking research opens up a new frontier in pancreatic cancer treatments by “waking up” the immune system to recognize and attack cancer cells effectively. While there is still much work to be done before human trials can begin, this discovery holds great promise for improving patient outcomes and potentially saving lives. As we continue to learn more about how our bodies fight against disease, it’s clear that understanding these complex interactions will play a crucial role in developing effective treatments for years to come.
Source: [Original Article](https://www.foxnews.com/health/new-pancreatic-cancer-treatment-wakes-up-immune-cells-researchers-say)
#pancreatic
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